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. 2023 May 31;8(9):1160–1176. doi: 10.1016/j.jacbts.2023.03.003

Figure 1.

Figure 1

The Effects of rhNRG-1β on the Development of CKD at Week 10

(A) NRG-1β protein expression in left ventricles and (B) kidney tissue at week 10 in 5/6 nephrectomized rats (unpaired Student t test). (C) Serum carbamide concentration, (D) serum creatinine concentration, (E) urine protein concentration, (F) creatinine clearance, (G) plasma p-cresyl sulfate concentration, and (H) plasma indoxyl sulfate concentration at week 10. Values are presented as mean ± SEM. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, n = 7-10, 1-way analysis of variance, Holm-Sidak post hoc test. CKD = chronic kidney disease group; CKD + rhNRG-1β = recombinant human neuregulin-1β-treated chronic kidney disease group; LV = left ventricular; Sham = sham-operated group.