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. 2023 Aug 1;83(19):3192–3204. doi: 10.1158/0008-5472.CAN-23-0285

Figure 3.

Figure 3. AR promotes SLC7A11 expression at transcriptional level. A, Meta-analysis of ChIP data of transcription factors that potentially bind to the SLC7A11 gene locus using the online-based platform Cistrome software (http://dbtoolkit.cistrome.org). B and C, UCSC screenshot of AR ChIP-Seq showing AR occupancy at the SLC7A11 loci in LNCaP and C4–2 cells cultured in CSS medium and treated with or without DHT (B), and qChIP-PCR analysis of AR binding at the SLC7A11 promoter and enhancer regions in LNCaP and C4–2 (C) cells with the same treatment as in B. D and E, AR ChIP-Seq occupancy profiles at the SLC7A11 loci in C4–2 cells treated with or without ENZ (D). qChIP-PCR confirming AR binding at the SLC7A11 promoter and enhancer region was abolished in C4–2 cells (E) with the same treatment as in D.

AR promotes SLC7A11 expression at transcriptional level. A, Meta-analysis of ChIP data of transcription factors that potentially bind to the SLC7A11 gene locus using the online-based platform Cistrome software (http://dbtoolkit.cistrome.org). B and C, UCSC screenshot of AR ChIP-Seq showing AR occupancy at the SLC7A11 loci in LNCaP and C4–2 cells cultured in CSS medium and treated with or without DHT (B), and qChIP-PCR analysis of AR binding at the SLC7A11 promoter and enhancer regions in LNCaP and C4–2 (C) cells with the same treatment as in B. D and E, AR ChIP-Seq occupancy profiles at the SLC7A11 loci in C4–2 cells treated with or without ENZ (D). qChIP-PCR confirming AR binding at the SLC7A11 promoter and enhancer region was abolished in C4–2 cells (E) with the same treatment as in D.