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. 2023 Sep 27;16:2677–2686. doi: 10.2147/CCID.S427956

Table 1.

Target Pathways in the Melanin Life Cycle and Key Ingredients in Dark Spot Treatment

Melanin Life Cycle Pathway Dark Spot Treatment Ingredients
Melanocyte activation Tranexamic acid
Niacinamide
Vitamin C (tetrahexyldecyl ascorbate)
Melanosome development Lotus sprout extract
Melanin production Lotus sprout extract
Phenylethyl resorcinol
Kojic acid (kojic dipalmitate)
Vitamin C (tetrahexyldecyl ascorbate)
Melanin distribution Niacinamide
Melanosome degradation Lotus sprout extract
Melanin removal Retinol
Glycolic acid