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. 2023 Sep 7;66(18):12697–12709. doi: 10.1021/acs.jmedchem.3c01101

Figure 7.

Figure 7

Oxetanes in drug discovery programs (2017–2022). (a) Selected examples in scientific articles. (b) Occurrence of the most popular oxetane building blocks used (from the refs in the Supporting Information). (c) Examples of recent methodologies developed for the synthesis of 3,3-disubstituted oxetanes.28c,29a hWBu = human whole blood, unbound potency; IL-2, interleukin 2; and Pks13 = polyketide synthase 13.