Table 2. Binding Affinities of the Fluorescent Ligands in CXCR2 Membranes, CXCR2 Whole Cells, and CXCR1 Membranes Determined by Saturation Binding Assays.
|
KD ± SEMa (nM) |
|||
|---|---|---|---|
| compound | CXCR2 membranes | CXCR2 whole cells | CXCR1 membranes |
| 11a | 137 ± 12 | 549 ± 83 | |
| 11c | 301 ± 31 | ||
| 11d | 9.0 ± 4.9 | 52 ± 7 | 101 ± 21 |
| 11e | 45 ± 4 | 82 ± 14 | |
| 11f | 27 ± 3 | 88 ± 23 | 372 ± 107 |
All values represent mean ± SEM of n = 5 separate experiments.