Table 2.
Laboratory parameters of the studied cohort
| Variable | LC with HCC n = 37 |
LC n = 30 |
Controls n = 20 |
P-value | P1 | P2 | P3 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total bilirubin (mg/dl) | |||||||||||||||
| Mean ±SD | 3.33 ±4.87 | 2.95 ±4.87 | 0.57 ±0.19 | 0.0001 | 0.66 | 0.0001 | 0.0001 | ||||||||
| Median (range) | 1.5 (0.2-23) | 1.65 (0.3-27) | 0.55 (0.2-1) | ||||||||||||
| ALT (IU/l) | |||||||||||||||
| Mean ±SD | 72.7 ±130.58 | 27.17 ±29.35 | 15.95 ±7.26 | 0.0001 | 0.001 | 0.0001 | 0.12 | ||||||||
| Median (range) | 38 (10-636) | 18 (6-160) | 13.5 (9-32) | ||||||||||||
| AST (IU/l) | |||||||||||||||
| Mean ±SD | 96.95 ±151.58 | 55.83 ±44.44 | 21.05 ±12.94 | 0.0001 | 0.06 | 0.0001 | 0.0001 | ||||||||
| Median (range) | 54 (12-885) | 43 (14-208) | 18.5 (12-70) | ||||||||||||
| Albumin (g/dl) | |||||||||||||||
| Mean ±SD | 3.3 ±0.79 | 2.62 ±0.61 | 3.74 ±0.44 | < 0.0001 | < 0.0001 | 0.06 | < 0.0001 | ||||||||
| Median (range) | 3.5 (1.4-4.6) | 2.65 (1.5-4) | 3.8 (3-4.5) | ||||||||||||
| PT (sec) | |||||||||||||||
| Mean ±SD | 15.58 ±3.37 | 16.08 ±2.13 | 12.06 ±1.67 | < 0.0001 | 1.0 | < 0.0001 | < 0.0001 | ||||||||
| Median (range) | 15 (12-26) | 16 (13-21) | 11.85 (10-16) | ||||||||||||
| PC (%) | |||||||||||||||
| Mean ±SD | 74.94 ±18.14 | 61.85 ±14.25 | 96.40 ±18.01 | < 0.0001 | 0.007 | < 0.0001 | < 0.0001 | ||||||||
| Median (range) | 76.7 (35-98) | 61.25 (41-88) | 97.6 (66.3-124) | ||||||||||||
| INR | |||||||||||||||
| Mean ±SD | 1.23 ±0.3 | 1.33 ±0.22 | 0.96 ±0.15 | < 0.0001 | 0.31 | 0.001 | < 0.0001 | ||||||||
| Median (range) | 1.1 (0.9-2.09) | 1.3 (1-1.8) | 0.95 (0.7-1.2) | ||||||||||||
| WBCs (103/ul) | |||||||||||||||
| Mean ±SD | 7.04 ±4.4 | 8.93 ±7.69 | 8.9 ±4.06 | 0.07 | 0.3 | 0.02 | 0.21 | ||||||||
| Median (range) | 6 (2-26) | 6.6 (2.6-40) | 9.4 (3-20) | ||||||||||||
| Haemoglobin (gm/dl) | |||||||||||||||
| Mean ±SD | 11.42 ±2.46 | 10.03 ±2.60 | 12.02 ±1.27 | 0.008 | 0.048 | 1.00 | 0.01 | ||||||||
| Median (range) | 12 (6.6-16) | 10.6 (5.5-15) | 12 (9.5-14) | ||||||||||||
| Platelets (103/ul) | |||||||||||||||
| Mean ±SD | 174.59 ±104.05 | 116.26 ±57.84 | 302.9 ±90.08 | < 0.0001 | 0.01 | 0.0001 | 0.0001 | ||||||||
| Median (range) | 153 (40-561) | 107.5 (40-246) | 307 (152-500) | ||||||||||||
| Na (mEq/l) | |||||||||||||||
| Mean ±SD | 134.05 ±5.14 | 134.4 ±6.4 | 138.65 ±2.5 | 0.005 | 1 | 0.006 | 0.02 | ||||||||
| Median (range) | 134 (121-146) | 135.5 (112-142) | 139 (134-143) | ||||||||||||
| Creatinine (mg/dl) | |||||||||||||||
| Mean ±SD | 1.48 ±1.01 | 1.53 ±0.93 | 0.69 ±0.23 | 0.0001 | 0.55 | 0.0001 | 0.0001 | ||||||||
| Median (range) | 1.2 (0.5-5) | 1.2 (0.7-5) | 0.65 (0.4-1.4) | ||||||||||||
| Urea (mg/dl) | |||||||||||||||
| Mean ±SD | 49.42 ±23.77 | 68.53 ±25.28 | 33.7 ±11.63 | 0.0001 | 0.0009 | 0.01 | 0.0001 | ||||||||
| Median (range) | 42 (20-123) | 59 (20-124) | 33.5 (16-55) | ||||||||||||
| Cholesterol (mg/dl) | |||||||||||||||
| Mean ±SD | 142.56 ±63.2 | 113.3 ±38.58 | 169.5 ±32.65 | 0.0001 | 0.04 | 0.03 | 0.0001 | ||||||||
| Median (range) | 145 (37-320) | 101 (49-230) | 172 (108-223) | ||||||||||||
| Triglycerides (mg/dl) | |||||||||||||||
| Mean ±SD | 164.84 ±64.21 | 147.27 ±70.59 | 131.05 ±51.82 | 0.12 | 0.21 | 0.04 | 0.51 | ||||||||
| Median (range) | 156 (55-356) | 136.5 (39-343) | 122.5 (65-262) | ||||||||||||
| Blood glucose (mg/dl) | |||||||||||||||
| Mean ±SD | 114.76±39.16 | 149.77±63.94 | 93.4±29.17 | 0.0009 | 0.04 | 0.004 | 0.002 | ||||||||
| Median (range) | 100 (73:243) | 135 (56:260) | 84.5 (70:200) | ||||||||||||
| Serum visfatin (ng/dl) | |||||||||||||||
| Mean ±SD | 14.18 ±5.4 | 10.88 ±2.54 | 10.12 ±4.81 | 0.001 | 0.0001 | 0.0001 | 0.03 | ||||||||
| Median (range) | 13.19 (8.21-39.11) | 10.39 (7.63-18.68) | 9.16 (0.54-26.16) | ||||||||||||
| Serum vaspin (ng/dl) | |||||||||||||||
| Mean ±SD | 408.19 ±68.24 | 304.47 ±55.7 | 216.1 ±55.07 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | ||||||||
| Median (range) | 394 (313-588) | 301 (190-410) | 206.5 (81-316) | ||||||||||||
P-value compared the three groups, P1 compared HCC & LC, P2 compared HCC & controls, and P3 compared LC & controls. ALT – alanine transaminase, AST – aspartate transaminase, PT – prothrombin time, PC – prothrombin concentration, INR – international normalized ratio, WBCs – white blood cells