Figure 2.

Pathological Gene Expression Signatures Decrease Following LVAD Therapy

(A) qPCR analysis of 18S ribosomal RNA expression expressed as starting quantity normalized to the pre–left ventricular assist device (LVAD) group. (B) Atrial natriuretic factor (NPPA) gene expression normalized to 18S. (C) B-type natriuretic peptide (NPPB) gene expression normalized to 18S. (D) β-myosin heavy chain (MYH7) gene expression normalized to 18S. (E) α-myosin heavy chain (MYH6) gene expression normalized to 18S. (F) α-skeletal muscle actin (ACTA1) gene expression normalized to 18S. n = 16 pre-LVAD, 16 post-LVAD. Data are presented as mean ± SEM and were analyzed by 2-tailed paired Student's t-test; ∗∗P < 0.01, ns = not significant. Outliers >2 SDs from the mean were removed.