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. 2023 Aug 1;34(8):881–889. doi: 10.5152/tjg.2023.22293

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Figure 3. — Effect of SIX1 knockdown on apoptosis and drug resistance in the presence of sorafenib. (A) Silencing of SIX1 promoted cell apoptosis. Apoptotic cells were analyzed using a BD Accuri C6 flow cytometer via Annexin PE/7-AAD staining. The percentage of apoptotic and living cells is shown. (B) Western blotting was used to investigate the expression levels of the c-PARP protein in SNU398 (parental), shSIX1-SNU398, and control-SNU398 cells. The c-PARP levels were increased in shSIX1-SNU398 cells compared to control-SNU398 cells with 5 µM sorafenib. β-Actin was used as the loading control. SIX1, SIX1, Sine oculis homeoprotein 1. ^** P < .001, ***P < .0001.