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. 2023 Sep 30;21:268. doi: 10.1186/s12964-023-01297-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — E6446 is more potent and safer than A939572 in preventing adipogenic differentiation and hepatic lipogenesis. The effect of different concentrations of E6446 and A939572 on LDH release and cellular viability in OP cells (A-B) and AML12 cells (C-D). For adipogenic differentiation, OP9 cells were incubated with 1 μM rosiglitazone for 15 days to induce adipogenic differentiation. The effect of E6446 and A939572 on E cellular TG level, F mRNA expression of adipogenic differentiation-related genes, and G Oil Red O staining (scale bar: 200 μm, 250 μm). During lipogenesis, AML12 cells were incubated with E6446 (10 μM) or A939572 (10 μM). The effect of E6446 and A939572 on H cellular TG level. I mRNA expression of lipogenesis-related genes, and (J) Oil Red O staining (scale bar: 200 μm, 250 μm). K Biacore X100 detected the kinetics/Affinity of E6446 and A939572 with SCD1. The values presented are the means ± SEMs of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001 vs. the Control group. ^#P < 0.05, ^##P < 0.01, vs. E6446 group