Figure 2. i8-YT-KO mice develop aortic aneurysms.

(A) Echocardiography was used to determine aortic diameter in anesthetized mice. (B–E) The systolic and diastolic diameter of the abdominal aorta and systolic and diastolic wall tension at 6 weeks are shown (n = 6). (F) The aortic lumen diameter of abdominal (n ≥ 6) and thoracic (n ≥ 5) aortae in perfusion-fixed aortic specimens at 2 and 8 weeks. *P < 0.05; **P < 0.01; ***P < 0.001 by 2-tailed Student’s t test (B–F).