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. 2023 Sep 8;8(17):e170513. doi: 10.1172/jci.insight.170513

Figure 2. Treatment of human OA chondrocytes with the class I HDAC inhibitors.

Figure 2

(A) Cells were treated with entinostat, chidamide, mocetinostat, or DMSO, and RNA was collected 24 hours after initiation of treatment. mRNA levels are expressed as mean ± SEM, relative to DMSO (n = 4 donors). *P < 0.05, **P < 0.01, Dunnett’s test versus DMSO. Results of 1-way mixed-effects ANOVA test are shown in Supplemental Table 17. (B) Cells were treated with 30 μM of mocetinostat or DMSO, and RNA was collected 24 hours after initiation of treatment. mRNA levels are expressed as mean ± SEM, relative to DMSO (n = 6 donors). **P < 0.01, paired t test. HDAC, histone deacetylase.