Figure 7. Chemical inhibition of PGC-1α in mocetinostat-treated OA chondrocytes.

Cells were treated with 30 μM mocetinostat or DMSO (n = 5 donors). To inhibit PGC-1α activity, 50 μM of SR-18292 was used. RNA was collected 24 hours after initiation of treatment. mRNA levels are expressed as mean ± SEM, relative to DMSO. *P < 0.05, **P < 0.01, Dunnett’s test versus mocetinostat. Results of 1-way mixed-effects ANOVA test are shown in Supplemental Table 17.