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. 2023 Oct 2;25:189. doi: 10.1186/s13075-023-03149-w

Table 1.

The regulators involved in m6A methylation

Category Genes Function
Writers METTL3, METTL14, WTAP, KIAA1492 METTL3 and METTL14 form complexes that catalyze the m6A methylation of RNA with WTAP and other factors such as KIAA1429.
Erasers FTO, ALKBH5 The m6A modified base is demethylated by FTO and ALKBH.
Readers YTHDC1, YTHDC2, YTHDF1, YTHDF2, YTHDF3 Recognizing RNA methylation modification information, participating in downstream RNA translation, degradation, and other processes.