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. 2023 Sep 18;11:1261048. doi: 10.3389/fcell.2023.1261048

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Copyright © 2023 Ptashnik, LaMassa, Mambetalieva, Schnall, Bucaro and Phillips.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pseudophosphorylation at S759 and S762 affects trafficking of the full length molecule. (A) Cells were transfected with full length Pcdh-γA3 or Pcdh-γA3 SSEE. Junctions between two cells (arrowheads) were identified. (B) Quantification of cell junctions per 50 transfected cells. The number of junctions formed by Pcdh-γA3 SSEE was significantly increased relative to wild-type Pcdh-γA3 (left) while the number of transfected cells was equivalent between the 2 constructs (right). Bar = 5 μm ***p <0.001.