Table 3.
Stratified analyses of association between alcohol consumption and serum α−klotho levels concentrations (pg/mL)
| Alcohol consumption | P for interaction | |||||
|---|---|---|---|---|---|---|
| Never | Former | Current Light | Current Moderate | Current Heavy | ||
| Age | 0.970 | |||||
| 40−59 | 0 | −16.96(−57.20 ~ 23.29) | −24.15(−58.56 ~ 10.25) | −63.46(−96.82 ~ −27.09) | −80.85(−118.68 ~ −43.01) | |
| 60−79 | 0 | −17.16(−48.80 ~ 14.48) | −12.23(−41.28 ~ 16.80) | −58.17(−92.59 ~ −23.75) | −80.88(−122.34 ~ −39.41) | |
| Sex | 0.240 | |||||
| Female | 0 | −31.07(−63.78 ~ 1.65) | −26.99(−54.34 ~ 0.36) | −84.23(−111.99 ~ −56.47) | −111.15(−156.42 ~ −65.88) | |
| Male | 0 | 5.17(−52.31 ~ 62.64) | −4.18(− 49.43 ~ 41.07) | −34.49(−85.92 ~ 16.94) | −56.77(−106.37 ~ −7.18) | |
| BMI | 0.196 | |||||
| Normal weight | 0 | −30.14(−78.33 ~ 18.05) | −10.13(−58.34 ~ 38.09) | −42.51(−91.59 ~ 6.57) | −71.06(−131.76 ~ −10.36) | |
| Overweight | 0 | −7.97(−49.48 ~ 33.53) | −39.45(−75.68 ~ −3.22) | −73.45(−124.93 ~ −21.98) | −91.73(−150.94 ~ −32.51) | |
| Obese | 0 | −17.15(−58.63 ~ 24.33) | −7.10(−42.51 ~ 28.30) | −68.33(−109.06 ~ −27.59) | −80.30(−120.209 ~ −40.52) | |
| Hypertension | 0.986 | |||||
| No | 0 | −1.84(−35.35 ~ 31.67) | −5.45(−39.01 ~ 28.10) | −48.65(−82.41 ~ −14.89) | −63.34(−100.64 ~ −26.04) | |
| Yes | 0 | −27.88(−68.45 ~ 12.69) | −32.18(−67.49 ~ 3.12) | −74.70(−115.86 ~ −33.53) | −99.83(−142.09 ~ −57.56) | |
| CKD | 0.088 | |||||
| No | 0 | −20.88(−50.38 ~ 8.63) | −25.79(−50.06 ~ 0.47) | −66.34(−95.78 ~ −36.91) | −93.29(−126.79 ~ −59.80) | |
| Yes | 0 | 5.90(−55.30 ~ 67.09) | 3.56(−47.97 ~ 55.08) | −50.84(−127.78 ~ 26.11) | −14.91(−84.12 ~ 54.29) | |
| CVD | 0.528 | |||||
| No | 0 | −13.14(−43.39 ~ 17.12) | −20.66(−45.86 ~ 4.55) | −64.79(−92.74 ~ −36.85) | −83.92(−114.63 ~ −53.21) | |
| Yes | 0 | −25.86(−85.07 ~ 33.34) | −10.29(−77.68 ~ 57.09) | −24.43(−94.22 ~ 45.36) | −49.38(−142.61 ~ 43.86) | |
| Cancer | 0.156 | |||||
| No | 0 | −15.93(−44.80 ~ 12.93) | −22.32(−49.64 ~ 1.01) | −59.13(−87.15 ~ −31.11) | −84.12(−116.08 ~ −52.16) | |
| Yes | 0 | −19.40(−89.77 ~ 50.96) | 8.24(−54.95 ~ 71.45) | −82.96(−160.92 ~ −5.01) | −51.04(−126.00 ~ 23.93) | |
Each stratification adjusted for all factors (age, sex, race/ethnicity, BMI, GGT, marital status, education level, PIR, smoking status, diabetes, hypertension, CKD, CVD, COPD, and cancer) except the stratification factor itself
Abbreviations: BMI Body mass index, GGT Gamma-glutamyl transferase, PIR Ratio of family income to poverty, CKD Chronic kidney disease, CVD Cardiovascular disease, COPD Chronic obstructive pulmonary disease