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. 2023 Oct 2;21:271. doi: 10.1186/s12964-023-01273-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — LINC00707 is expressed in brain tumors and negatively correlates with pSmad2 levels. A RNAscope for LINC00707 expression in a glioblastoma tumor derived from human U2987MG cells orthotopically injected to the mouse brain. Panel a shows co-staining for LINC00707 and DAPI; panels b and c show the separate channels. B RNAscope for LINC00707 and immunohistochemistry for pSmad2 expression in a glioblastoma tumor derived from human U2987MG cells. Panel a shows co-staining for LINC00707/pSmad2/DAPI; panels b (LINC00707), c (pSmad2) and d (DAPI) show the separate channels. C RNAscope for LINC00707 and immunohistochemistry for pSmad2 expression in a glioblastoma tumor derived from human U2987MG cells. The magnified panel a shows a LINC00707^High/pSmad2^Low area, the magnified panel b shows a LINC00707^Low/pSmad2^High and the magnified panel c shows a LINC00707-negative adjacent mouse tissue area. Scale bars: 50 μm (main panel), 10 μm (magnified panels)