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. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Alzheimers Dement. 2023 Mar 30;19(10):4651–4661. doi: 10.1002/alz.13036

Figure 2. Three-way interaction between sex, APOE and time on cognitive decline in non-Hispanic White (NHW) participants in Sample 1 (NACC & ROS/MAP).

Figure 2.

Plots depict marginal effects, showing change in cognition (standardized score) over time, stratified by sex and genotype (APOE ε4 plot not shown). In sex-stratified analyses, men carrying APOE ε2 were more protected against decline than men carrying APOE ε3/ε3. In women, APOE ε2 was no more protective than APOE ε3/ε3. In genotype-stratified analyses, men carrying APOE ε2 were more protected against decline than women carrying APOE ε2. By contrast, rates of decline did not differ between men and women APOE ε3/ε3 carriers. The models are adjusted for baseline age, years of education, and vascular risk, and their interactions with time. Shaded regions represent 95% confidence intervals.