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. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Alzheimers Dement. 2023 Mar 30;19(10):4651–4661. doi: 10.1002/alz.13036

Figure 3. Three-way interaction between sex, APOE and time on cognitive decline in non-Hispanic White (NHW) participants in Sample 2 (ADNI & Prevent-AD).

Figure 3.

Plots depict marginal effects showing change in cognition (standardized score) over time, stratified by sex and genotype (APOE ε4 plot not shown). Sex-stratified analyses were not significant. In genotype-stratified analyses, men carrying APOE ε2 were more protected against decline than women carrying APOE ε2, whereas the rates of decline did not differ between men and women carrying APOE ε3/ε3. The models are adjusted for baseline age, years of education, and vascular risk, and their interactions with time. Shaded regions represent 95% confidence intervals.