Table 2.

Sex-specific associations between APOE ε2 (vs APOE ε3/ε3) and longitudinal cognition in non-Hispanic White participants.

Analyses	Sample 1 (NACC & ROS/MAP)		NACC		ROS/MAP		Sample 2 (ADNI & Prevent-AD)
	β (95% CI)	p	β (95% CI)	p	β (95% CI)	p	β (95% CI)	p
Three-way interaction:
Sex × APOE ε2 (vs. ε3/ε3) × time	0.097 (0.023 – 0.172)	.01	0.081 (0.010 – 0.152)	.02	0.127 (−0.069 – 0.323)	.20	0.195 (0.006 – 0.385)	.04
Sex-stratified two-way interactions:
APOE ε2 (vs. ε3/ε3) × time in men	0.096 (0.037 – 0.155)	.001	0.074 (0.020 – 0.128)	.008	0.149 (−0.022 – 0.319)	.09	0.093 (−0.056 – 0.243)	.22
APOE ε2 (vs. ε3/ε3) × time in women	−0.001 (−0.044 – 0.043)	.97	−0.008 (−0.051 – 0.035)	.71	0.012 (0.089 – 0.114)	.81	−0.104 (−0.228 – 0.020)	.10
Genotype-stratified two-way interaction:
Male sex × time in APOE ε2 carriers	0.120 (0.051 – 0.190)	.001	0.095 (0.028 – 0.161)	.005	0.191 (0.012 – 0.371)	.04	0.160 (−0.002 – 0.321)	.05
Male sex × time in APOE ε3/ε3 carriers	−0.000 (−0.031 – 0.030)	.99	−0.005 (−0.033 – 0.024)	.75	0.038 (−0.044 – 0.121)	.36	−0.009 (−0.091 – 0.074)	.84

NACC: National Alzheimer’s Coordinating Center

ROS: Religious Orders Study

MAP: Memory Aging Project

ADNI: Alzheimer’s Disease Neuroimaging Initiative

Prevent-AD: Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer Disease

CI: confidence interval