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. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2023 Aug 31;43(10):1764–1774. doi: 10.1161/ATVBAHA.123.319023

Figure 1. Mechanistic pathways mediating the roles of both obesity/adiposity severity and duration in cardiovascular and metabolic disease pathogenesis.

Figure 1.

This figure summarizes the available evidence from human translational and animal studies supporting the diverse roles for obesity severity and duration in the pathophysiology of various cardiovascular diseases and associated conditions affecting cardiovascular risk. Dysfunctional adipose tissue mediates the pathogenesis through numerous mechanisms. Less is known about potentially unique means through which obesity duration impacts the development of these disorders, and the potential for their resolution/improvement with weight loss.

Created with BioRender.com. ASCVD, atherosclerotic cardiovascular disease; RAAS, renin-angiotensin- aldosterone system