FIG. 4.

Efficacies of CS-834 and reference antibiotics against pneumonia caused by penicillin-resistant strains 9605 (A) and 9601 (B). Each column and bar represents the mean ± standard error (n = 8 to 10). The indicated doses of each drug were administered orally twice daily for 2 days beginning at 24 h after infection, and the numbers of viable cells in the lungs and blood of mice were determined at 72 h after infection. CFTM-PI, cefteram pivoxil; CPDX-PR, cefpodoxime proxetil; CFDN, cefdinir; CDTR-PI, cefditoren pivoxil. The asterisks indicate a significant difference (P < 0.05) compared with the results for the control group.