TABLE 2.

Pharmacokinetic parameters of the study antibiotics in mouse plasma and lung^a

Compartment and drug	Tmax (h)	Cmax (μg/ml or g)	t1/2 (h)	AUC0–6 (μg · h/ml or g)
Plasma
R-95867	0.63 ± 0.13	43.8 ± 5.4	0.48 ± 0.06	55.8 ± 3.84
CPDX	0.50 ± 0	111 ± 6.8	1.52 ± 0.16	127 ± 6.52
CFTM	0.50 ± 0	88.7 ± 9.1	1.52 ± 0.16	149 ± 5.51
CDTR	0.69 ± 0.19	86.2 ± 1.3	1.54 ± 0.13	209 ± 14.1
CFDN	0.50 ± 0	15.2 ± 3.0	2.84 ± 0.30	37.8 ± 1.77
Lung
R-95867	0.63 ± 0.13	9.10 ± 0.75	NC	9.04 ± 0.67
CPDX	0.44 ± 0.06	38.6 ± 4.2	2.20 ± 0.63	49.2 ± 2.51
CFTM	0.50 ± 0	33.0 ± 6.7	0.41 ± 0.25	40.7 ± 7.61
CDTR	0.50 ± 0	29.8 ± 0.81	2.85 ± 0.23	77.5 ± 3.97
CFDN	ND	ND	ND	ND

^aAbbreviations: T_max, time to maximum concentration of drug in serum or lungs; C_max, maximum concentration of drug in serum or lungs; t_1/2, half-life; AUC_0–6, area under the concentration-time curve from time zero to 6 h; CPDX, cefpodoxime; CFTM, cefteram; CDTR, cefditoren; CFDN, cefdinir; NC, not calculated (insufficient datum points); ND, not detected.