Table 2.

Univariate and multivariable Cox regression analysis on overall survival.

	Univariate Cox			Multivariate Cox
Variables	HR	95% CI	P-value	HR	95% CI	P-value
TYK2 (high vs low)	0.351	0.194 to 0.637	<.001	0.36	0.185 to 0.699	.003
Age (>60 vs ≤60)	0.806	0.454 to 1.429	.46	0.774	0.416 to 1.441	.419
Gender (male vs female)	0.297	0.151 to 0.586	<.001	0.508	0.279 to 0.714	.009
AJCC stage (III–IV vs I–II)	0.782	0.366 to 1.672	.057	0.823	0.192 to 3.524	.793
Tumor stage (T3–4 vs T1–2)	1.451	1.363 to 1.656	.044	1.017	0.292 to 3.541	.978
Lymph node status (N2–3 vs N0–1)	1.894	1.060 to 3.383	.038	1.996	1.013 to 3.935	.046
Metastasis (M1 vs M0)	4.86	1.670 to 14.146	.004	2.147	1.632 to 7.292	.021
Race (White vs no White)	1.421	0.748 to 2.699	.284	0.587	0.286 to 1.203	.146
Alcohol history (no vs yes)	1.497	0.846 to 2.650	.166	1.273	0.670 to 2.421	.461
Smoking history (no vs yes)	1.061	0.588 to 1.912	.166	1.134	0.604 to 2.129	.695

CI = confidence interval, HR = hazard ratio, TYK2 = tyrosine kinase 2.