Skip to main content
. Author manuscript; available in PMC: 2023 Oct 2.
Published in final edited form as: Toxicol Sci. 2019 Apr 1;168(2):349–364. doi: 10.1093/toxsci/kfz006

Figure 8:

Figure 8:

There are 35 unique linear AOPs (LAOPs) between MIE:201 and AO:341. A) These LAOPs form a small subnetwork. B) Topological sorting can be used to visualize which KEs occur upstream and downstream of each other, and can help identify causal relationships. A shortest path analysis can be used to identify LAOPs of interest in this subnetwork, such as C) the shortest LAOP from MIE to AO (highlighted in light blue), D) the shortest LAOPs that only includes adjacent KERs (in this subnetwork there 5 unique LAOPs of equal length that meet these criteria, each highlighted in a different shade of blue), and E) the LAOP that only includes adjacent KERs and has the greatest combined weight of evidence score (highlighted in purple).