TABLE 1.
Relationship between KDM6B expression and clinicopathological factors
| KDM6B expression | |||
|---|---|---|---|
| Clinicopathological factor | High (n=62) | Low (n=25) | p |
| Sex | 0.901 | ||
| Male | 43 | 17 | |
| Female | 19 | 8 | |
| Age (mean±SD) (y) | 69±11 | 69±8 | 1.000 |
| HBV | 18 | 2 | 0.035a |
| HCV | 21 | 3 | 0.038a |
| NBNC | 23 | 20 | <0.001a |
| NAFLD | 9 | 20 | <0.001a |
| NASH | 7 | 19 | <0.001a |
| Obesity | 17 | 18 | <0.001a |
| Hypertension | 28 | 20 | 0.003a |
| Diabetes | 21 | 9 | 0.553 |
| Dyslipidemia | 10 | 7 | 0.206 |
| Child-Pugh A/B | 58/4 | 25/0 | 0.190 |
| Plt (<10×104) | 10 | 2 | 0.320 |
| PT (<80%) | 14 | 9 | 0.199 |
| Alb (<3.5 g/dL) | 8 | 4 | 0.705 |
| AST (>40 IU/L) | 25 | 9 | 0.708 |
| ALT (>40 IU/L) | 20 | 9 | 0.738 |
| Tbil (>1.0 mg/dL) | 8 | 6 | 0.212 |
| ICG-15 (>15%) | 24 | 14 | 0.140 |
| AFP (>20 ng/mL) | 31 | 4 | 0.003a |
| PIVKA-II (>40 mAU/mL) | 35 | 12 | 0.474 |
| Tumor size (>5 cm) | 23 | 5 | 0.122 |
| Tumor number (>2) | 11 | 9 | 0.067 |
| Differentiation (well, moderate/poor) | 45/10 | 24/1 | 0.089 |
a
Statistical significance.
Abbreviations: Alb, albumin; ALT, alanine aminotransferase; AFP, alpha-fetoprotein; AST, aspartate aminotransferase; ICG-15, indocyanine green retention rate at 15 minutes; NBNC, nonhepatitis B and nonhepatitis C viral; PIVKA-II, protein induced by vitamin K absence II; Plt, platelet; PT, prothrombin time; Tbil, total bilirubin.