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. 2023 Oct 2;12:RP88049. doi: 10.7554/eLife.88049

Figure 3. Lipodystrophy is uncoupled from detrimental metabolic effects in ADGAT DKO mice.

Figure 3.

(A) Adiponectin and leptin mRNA levels were moderately increased in inguinal white adipose tissue (iWAT) of ADGAT DKO mice. Relative mRNA levels of leptin and adiponectin in iWAT of chow-diet-fed male mice (n=6). (B) Plasma levels of adiponectin were normal, and leptin levels were moderately decreased in ad libitum chow-diet-fed male mice (n=8). (C). Plasma leptin levels normalized per gram of WAT mass (n=8). (D) ADGAT DKO mice had normal glucose and insulin levels. Glucose and insulin levels in ad libitum chow-diet-fed male mice (n=8). (E) Decreased free fatty acids in ADGAT DKO mice. Levels of plasma metabolites in ad libitum chow-diet-fed male mice (n=8). (F) Decreased ketones in ad libitum chow-diet-fed ADGAT DKO male mice (n=8). TG, triglycerides; CHOL, cholesterol; NEFA, non esterified fatty acids (G and H) Glucose and insulin tolerance tests were normal in chow-diet-fed male mice (n=10). (I) ADGAT DKO mice had non-steatotic livers. Representative photographs of livers from chow-diet-fed mice. (J) Triglycerides were moderately increased in livers of ADGAT DKO mice. Triglyceride levels in livers and skeletal muscle of chow-diet-fed male mice (n=6). Data are presented as mean ± SD. *p<0.05, **p<0.01, ***p<0.001.