Fig. 8.

ROI-level age effects: transient (positive-quadratic-age). Significant transient effects were localized to connectivity involved in salience detection (A, C; notably, two different functional parcellation locations within the right anterior cingulate gyrus) and integration (B, D). Light gray spheres indicate seed ROI and dark gray spheres indicate significant connections surviving FDR correction. See Table S6 for a full breakdown of connections. For better visualization, a representative connection (R ACG–L ORBmid) is plotted showing single-subject scatterplots with model fit curve overlaid (Fig. S15D). R ACG: right anterior cingulate gyrus; R ORBmed: right orbitofrontal cortex, medial; L IFGtriang: left inferior frontal gyrus, pars triangularis; L ORBmid: left orbitofrontal cortex, middle.