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. 2023 Aug 3;18(9):1827–1840. doi: 10.1016/j.stemcr.2023.07.002

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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VE-CADHERIN is expressed in a subpopulation of SHF cells during murine heart embryonic development on Ε8.5 and E9.5

(A) Stacked confocal microphotographs of a representative whole-mount embryo on E8.5 (somite stage 5) (a and b) phase-contrast image (c), and magnified areas from sections z2–z4 (c). All stacks are presented in Figure S5A and Video S1.

(B) Cryosections of heart development on E9.5, indicative of VE-CADHERIN (green) being expressed in SHF cell populations (ISL1⁺, red) destined to form future endocardial and pharyngeal endothelial structures. VE-CADHERIN⁺ cells were shown to co-localize with a subpopulation with MEF2c⁺ cells (left panel, blue) but not with cTNT⁺ (blue, center panel) cardiomyocytes or N-CADHERIN (blue, right panel). Arrows depict ISL1⁺/VE-CADHERIN⁺ cells. Scale bars, 20 μm.