Table 4.
Population pharmacokinetic model in healthy and malaria-infected adults66
| Parameter | Parameter estimate for healthy subjects (relative SE, %) |
Additive effect of infection on parameters in malaria patients (RSE, %)a | Between-subject variability (RSE, %) |
|---|---|---|---|
| Clearance (CL/F, L/day)b | 482 (4.54) | +584 (19.3) | 0.15 (9.8) |
| Volume of central compartment (V2/F, L) | 972 (8.00) | +8060 (4.58) | 0.381 (7.85) |
| Intercompartmental clearance (Q/F, L/day) | 1350 (1.3) | — | — |
| Volume of peripheral compartment (V3/F, L) | 6560 (4.44) | +10 700 (37.6) | 0.19 (15.7) |
| Absorption rate (ka, day−1) | 20.8 (7.26) | — | 0.486 (17.3) |
| Covariate model | |||
| Power exponent of age on CL/F | 0.130 (55.9) | — | — |
| Power exponent of weight on CL/F | 0.463 (36.3) | — | — |
| Residual error model | |||
| Additive error model [ln(ng/mL)] | 0.168 (0.7) | — | — |
RSE, relative standard error.
Apparent clearance (CL/F), volume of central compartment (V2/F) and volume of peripheral compartment (V3/F) in malaria patients were 1066 L/day, 9032 L and 17 260 L, respectively.
Parameters normalized to a body weight of 58 kg and age of 26 years.