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. 2023 Apr 21;146(10):4247–4261. doi: 10.1093/brain/awad132

Figure 1.

Figure 1

Effect of bumetanide on CCI-induced behavioural changes. (A) Schematic representation of the experimental timeline. (B) The object displacement task (ODT) after a 5 min retention time. (C) The novel object recognition (NOR) task after a 1-h retention time. (D) The NOR task after a 5-min retention time. For all experiments, the results are presented as a ratio of time of new versus familiar. n = 10, 11 and 10, respectively. (E) Time spent finding the target box in the Barnes maze (BM). (F) Number of entries into different zones of the elevated plus maze (EPM). (G) Time spent in different zones of the EPM. n = 3, 5 and 5, respectively. (H) Normalized spectral density of delta band in mice 1-month post-controlled cortical impact (CCI). (I) Normalized spectral density of theta band. (J) Normalized spectral density of gamma band. n = 6, 9 and 9, respectively. (K) Spike rate of narrow-spiking (NS) units. (L) Spiking rate of wide-spiking (WS) units. (M) Total number of isolated cells. Data in B were analysed using the Kruskal–Wallis test. Data in C–G, L and M were analysed using one-way ANOVA with Dunnett's post hoc test. Data in H–J were analysed using one-way ANOVA with Tukey’s post hoc test. *P < 0.05; **P < 0.01; ***P < 0.001. Bum = bumetanide; dpt = days post-testing.