Figure 5.

Observed versus predicted patterns of tau spreading in several stages of the Alzheimer’s disease continuum, for the second model. The first and third columns show the original results from the first model, using the control network as backbone, with the second and fourth columns showing the new results, based on the networks of the preceding disease stage, with the corresponding fit evaluating model performance. The rows display the observed clinical ¹⁸F-flortaucipir-PET BPND, and the predicted spreading patterns for the different (functional, structural, diffusion) networks. Warmer colours represent higher proportion of regional tau-binding. Note that in the predicted data, the seed region (ROI 14) is always infected with maximum tau binding. AD = Alzheimer’s disease; AEC-c = corrected amplitude envelope correlation; MCI = mild cognitive impairment.