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. 2023 May 24;44(10):2004–2018. doi: 10.1038/s41401-023-01101-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, b Western blot analyses of FGFR2 and phosphorylated FGFR2 expression in mouse heart tissues of the indicated groups at 12 h post doxorubicin injection. c Statistical analysis of the Western blotting data presented in a and b. d Immunoblot detection of FGFR2 and phosphorylated FGFR2 in HL-1 cells of indicated groups at 12 h post doxorubicin administration. e Immunoblot detection of total and phospho FGFR2 in FGFR2 stable expression HL-1 stable cells (Vector CONTROL, C383R and Y657/658F, respectively) with or without FGF10. f Statistical analysis of the immunoblot data presented in d and e. g Representative images of SOD, 53BP1, and TUNEL staining in DTG and CTRL mice. h Statistical analysis of the images presented in g. i Western blot analysis of C-CAS3 and SOD with GAPDH as an internal control in HL-1 cells. j Statistical analysis of the data presented in i. (DTG), Rosa26^rtTA/rtTA; tet(O) sFgfr2b/+, and the control mice (CTRL). ns, non-significant; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. Abbreviations: DTG, Rosa26^rtTA/rtTA; tet(O) sFgfr2b/+; CTRL, the control mice. Scaler bar: 100 μm.