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. 2023 Sep 1;55(9):2039–2050. doi: 10.1038/s12276-023-01082-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Structure-guided BMK-I-152 analog synthesis that replaced the exocyclic alkylamino group of BMK-I-152. b The IC₅₀ values of BMK-C203 and BMK-C205 (n = 3). c Liver microsomal stabilities (percentage remaining after 30 min) (n = 3). *Verapamil: reference chemical for liver microsomal stability (1 μM). d CYP450 inhibition assay (percentage of control activity at 10 μM). *Ketoconazole: CYP3A4 inhibitor (0.1 μM), reference chemical for the CYP450 inhibition assay (n = 3). e PK profiles of antalarmin, BMK-I-152, BMK-C203, and BMK-C205 in SD rats (n = 3).