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. 2023 Sep 1;55(9):2039–2050. doi: 10.1038/s12276-023-01082-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Timeline for behavioral testing was conducted 2 h after three consecutive days of drug treatment. Serum was isolated from the mice immediately after the TST application. The TST activates the HPA axis as a stressor. b Immobility times in drug-treated mice showed that only the BMK-C205 group was more mobile than the vehicle group. c ACTH concentrations in the serum from BMK-C203- and BMK-C205-treated mice were lower than those in the vehicle group. d CORT serum concentrations decreased in BMK-C205-treated mice compared to those in the vehicle group (vehicle n = 17, antalarmin n = 14, BMK-C203 n = 10, and BMK-C205 n = 13; **p < 0.01, ***p < 0.001, ANOVA). e ACTH serum levels were positively correlated with CORT levels (N = 54, Pearson’s r = 0.2849).