Fig. 6. XQ2B attenuates the host innate antiviral response in vivo.
a Chemical structure of XQ2 and XQ2B. b, c WT mice (n = 7) were injected intravenously with DMSO or XQ2B (10 mg/kg) for 3 h, and then administrated intravenously with HSV-1 at 1 × 107 pfu per mouse for 6 h. Serum from mice was collected for ELISA analysis of the levels of IFN-β (b) and CXCL10 (c). p = 0.0013 (b); p = 0.0175 (c). d Brains from mice (n = 6) in (b, c) were collected for qPCR analysis of the induction of HSV-1 and HSV-1(UL5) mRNA. p = 0.0287 (HSV-1); p = 0.0136 (HSV1-UL5). e Brains from mice in (b, c) were collected for immunohistochemistry (IHC) analysis with an anti-HSV-1 antibody. Tissue sections were visualized using microscopy. Scale bar, 25 μm. Data are representative of two independent experiments in (b–e). (Data are presented as mean ± SD, n = 7 mice per condition in (b, c); n = 6 mice per condition in (d), *p < 0.05, **p < 0.01 using one-way ANOVA with Dunnett’s post hoc test). Source data are provided as a Source Data file.