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. 2023 Jun 21;44(10):2075–2090. doi: 10.1038/s41401-023-01113-7

Fig. 3. PXR activation by rifampicin alleviates adenine-induced renal damage in PXR-humanized mice.

Fig. 3

a Schematic diagram of adenine-induced CKD with or without rifampicin (RIF) treatment. Adenine diet-fed PXR-humanized (hPXR) mice were treated with or without daily intragastric administration of RIF (10 mg/kg) for 28 days. b The gross view of the mice and the macroscopic appearance of the kidneys were photographed on day 29. RIF treatment reduced adenine-induced renal atrophy. RIF treatment significantly reduced the levels of sCr (c), BUN (d) and urinary albumin excretion (e) (n = 5). f H&E staining showed that RIF treatment mitigated renal tubular atrophy, dilatation with crystal deposition and cellular casts, and tubulointerstitial fibrosis. Scale bar: 100 μm. g The TI damage score of histopathologic features in f (n = 5). Results are expressed as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.