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. 2023 Jun 21;44(10):2075–2090. doi: 10.1038/s41401-023-01113-7

Fig. 5. PXR gene ablation exacerbates adenine-induced renal damages.

Fig. 5

a Gross view of the mice and the macroscopic appearance of the kidneys of mice treated with adenine or vehicle for 4 weeks. PXR gene knockout exacerbated adenine-induced body size reduction and granular appearance of the kidneys. PXR gene deficiency aggravated adenine-induced increase in sCr (b), BUN (c) and urinary albumin excretion (d) (n = 5–6). e The TI damage score of histopathologic features (n = 4–6). f H&E staining showing that PXR gene knockout aggravated renal tubular atrophy, dilatation with crystal deposition and cellular casts, and tubulointerstitial fibrosis. Scale bar: 100 μm. Results are expressed as mean ± SEM. **P < 0.01, ***P < 0.001.