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. 2023 Jun 21;44(10):2075–2090. doi: 10.1038/s41401-023-01113-7

Fig. 9. PXR activation and overexpression inhibit the Wnt7a/β-catenin signaling in cultured MTEC.

Fig. 9

a Western blot analysis demonstrating that PXR activation inhibited Wnt7a and β-catenin expression after TGFβ1 treatment in MTEC. b Semiquantitative analysis of the protein levels in a (n = 4). c Immunofluorescence assay showed that PXR activation inhibited the activation of β-catenin induced by TGFβ1 (5 ng/mL) for 24 h. Scale bar: 25 μm. d Western blot analysis demonstrated that PXR overexpression inhibited Wnt7a and β-catenin expression after TGFβ1 treatment in MTEC. e Semiquantitative analysis of the protein levels in d (n = 4). f Immunofluorescence assay showed that PXR activation inhibited the activation of β-catenin induced by TGFβ1 (5 ng/mL) for 24 h. Scale bar: 25 μm. Results are expressed as mean ± SEM. **P < 0.01, ***P < 0.001.