Table 1.
Regulation of cholesterol metabolism by noncoding RNA.
ncRNA | Targets | Mechanism | References |
---|---|---|---|
miR-128-1 | ABCA1, LDLR | Regulation of efflux and uptake | 72 |
miR-148a | ABCA1, LDLR | Regulation of efflux and uptake | 72,73 |
miR-130b | ABCA1, LDLR | Regulation of efflux and uptake | 72,74 |
miR-301b | ABCA1, LDLR | Regulation of efflux and uptake | 72 |
miR-185, | SR-B1 | Regulation of selective uptake of HDL-c | 74,75 |
miR-96 | SR-B1 | Regulation of selective uptake of HDL-c | 75 |
miR-223 | SR-B1 | Regulation of selective uptake of HDL-c | 75 |
miR-24 | SR-B1 | Regulation of cholesterol uptake | 76 |
miR-33 | SREBP2, ABCA1 | Upstream of ABCA1 | 77,78 |
miR-183 | ABCA1 | Regulation cholesterol efflux | 79,80 |
miR-26 | ABCA1 | Regulation cholesterol efflux | 84 |
miR-20a/b, | ABCA1 | Regulation cholesterol efflux | 81 |
miR-758 | ABCA1 | Regulation cholesterol efflux | 83 |
miR-19b | ABCA1 | Regulation cholesterol efflux | 82 |
miR-129-5p | ABCG1 | Upregulation of ABCG1 expression | 85 |
lncARSR | SREBP-2, HMGCR | Upregulation of SREBP-2 and HMGCR expression | 86 |
HULC | RXRA | Downregulation of miR-9 expression and upregulation of RXRA expression | 87 |
NEAT1 | miR-342-3p | Modulation of immune cell functions and lipid uptake | 88 |
ANRIL | Unknown | Modulation of the inflammatory response | 89 |
MALAT1 | ABCA1 | Regulation of cholesterol accumulation | 90 |