Table 1.
Baseline characteristics
| FHHD absent (N = 94 662) |
FHHD present (N = 72 052) |
Overall (N = 166 714) |
P-value | |
|---|---|---|---|---|
| Age | ||||
| Mean (SD) | 55.6 (8.35) | 57.1 (7.54) | 56.2 (8.05) | <0.001 |
| Sex | ||||
| Female | 50 250 (53.1%) | 42 692 (59.3%) | 92 942 (55.7%) | <0.001 |
| Male | 44 412 (46.9%) | 29 360 (40.7%) | 73 772 (44.3%) | |
| WHR | ||||
| Median [Min, Max] | 0.872 [0.506, 2.97] | 0.866 [0.484, 1.65] | 0.870 [0.484, 2.97] | <0.001 |
| Ever smoked status | ||||
| Absent | 53 113 (56.1%) | 40 594 (56.3%) | 93 707 (56.2%) | 0.347 |
| Present | 41 549 (43.9%) | 31 458 (43.7%) | 73 007 (43.8%) | |
| Hypertension | ||||
| Absent | 68 354 (72.2%) | 47 334 (65.7%) | 115 688 (69.4%) | <0.001 |
| Present | 26 308 (27.8%) | 24 718 (34.3%) | 51 026 (30.6%) | |
| History of diabetes | ||||
| Absent | 89 170 (94.2%) | 67 225 (93.3%) | 156 395 (93.8%) | <0.001 |
| Present | 5492 (5.8%) | 4827 (6.7%) | 10 319 (6.2%) | |
| Cholesterol medication use | ||||
| Absent | 83 528 (88.2%) | 59 047 (82.0%) | 142 575 (85.5%) | <0.001 |
| Present | 11 134 (11.8%) | 13 005 (18.0%) | 24 139 (14.5%) | |
| HeFH status | ||||
| Absent | 94 380 (99.7%) | 71 731 (99.6%) | 166 111 (99.6%) | <0.001 |
| Present | 282 (0.3%) | 321 (0.4%) | 603 (0.4%) | |
| PRSCAD | ||||
| Mean (SD) | 48.3 (28.8) | 53.3 (28.6) | 50.5 (28.9) | <0.001 |
| Lipoprotein(a) | ||||
| Median [Min, Max] | 18.0 [0.0200, 722] | 21.1 [0.0200, 743] | 19.3 [0.0200, 743] | <0.001 |
| hsCRP | ||||
| Median [Min, Max] | 1.30 [0.0800, 78.4] | 1.37 [0.0800, 79.5] | 1.33 [0.0800, 79.5] | <0.001 |
| Total cholesterol | ||||
| Mean (SD) | 221 (42.7) | 223 (43.5) | 222 (43.1) | <0.001 |
| LDL cholesterol | ||||
| Mean (SD) | 138 (32.5) | 140 (33.1) | 139 (32.8) | <0.001 |
| HDL cholesterol | ||||
| Mean (SD) | 56.5 (14.3) | 56.7 (14.1) | 56.6 (14.2) | 0.00839 |
| Triglycerides | ||||
| Median [Min, Max] | 129 [20.5, 988] | 134 [25.4, 999] | 131 [20.5, 999] | <0.001 |
| ApoA concentration | ||||
| Mean (SD) | 1.54 (0.259) | 1.55 (0.258) | 1.55 (0.258) | <0.001 |
| ApoB concentration | ||||
| Mean (SD) | 1.03 (0.232) | 1.05 (0.234) | 1.04 (0.233) | <0.001 |
| ApoB/ApoA ratio | ||||
| Mean (SD) | 0.687 (0.197) | 0.693 (0.197) | 0.690 (0.197) | <0.001 |
Baseline characteristics for the study population. The mean value is listed for normally distributed values. The median value is shown for non-normally distributed values.
ApoAI, apolipoprotein AI; ApoB, apolipoprotein B; ApoB:ApoAI, apolipoprotein B-to-apolipoprotein AI ratio; HDL, high-density lipoprotein; FHHD, family history of heart disease; HeFH, heterozygous familial hypercholesteremia; hsCRP, high sensitivity C-reactive protein; LDL, low-density lipoprotein; Lp(a), lipoprotein(a); PRSCAD Percentile, polygenic risk score for coronary artery disease; WHR, waist-to-hip ratio.