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. 2023 Oct 2;14:6137. doi: 10.1038/s41467-023-41881-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — In α-syn(A53T)^Tg and Aβ^Tg;α-syn(A53T)^Tg strains, piRNA dysregulation upregulates H3K9me3 to silence and/or directly target protein degradation genes which cause α-syn accumulation. After blocking piRNA biogenesis by knocking out the tofu-1 gene, piRNAs downregulate and decrease H3K9me3, while protein degradation gene expression increases, which improves the activity of protein degradation and decreases α-syn expression in C. elegans.