Table 1.

Potential risk factors for unfavorable outcome in AIHA.

Risk factor	Outcome	Source
Reticulocytopenia	Life-threatening/fatal	Case series. (8) Expert opinion. (4, 35)
Intravascular hemolysis (hemoglobinuria)	Life-threatening/fatal	Case series. (8) Expert opinion. (4, 35)
High indirect bilirubin at onset	ICU admission	AIHA cohort (23)
Low hemoglobin at onset (<8g/dl)	ICU admission	AIHA cohort (23)
	Relapse/multiple treatment lines	Primary AIHA cohort (12)
	Mortality	Primary AIHA cohort (18)
Serological type: wAIHA (IgG + complement), mixed, atypical.	Need for transfusion	Primary AIHA cohort (18)
	Multiple therapy lines	Primary AIHA cohort (12)
	Hospitalisation	Primary AIHA cohort (18)
Evans syndrome	Mortality	Primary AIHA cohort, case series (8, 12)
Infection	Mortality	Primary AIHA cohort (12)
Renal failure	Mortality	Primary AIHA cohort (12)
Multiple treatment lines	Mortality	Primary AIHA cohort (12)