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. 2023 Sep 19;13:1264785. doi: 10.3389/fonc.2023.1264785

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Copyright © 2023 Bray, Balcells, McNeish and Keun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The methionine cycle and interrelated pathways. The production and utilisation of SAM is central to the methionine cycle and allows protein methylation by methyltransferases. The methionine salvage cycle recovers methionine through the conversion of MTA to methionine via the analogue MTR. ACHY, adenosylhomocysteine; AMD1, adenosylmethionine decarboxylase 1; ASA, arginonosuccinic acid; MTR, methylthioribose; ODC, ornithine decarboxylase; SAH, S-adenosyl-homocysteine; THF, tetrahydrofolate.