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. 2023 Sep 19;13:1264785. doi: 10.3389/fonc.2023.1264785

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Copyright © 2023 Bray, Balcells, McNeish and Keun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PRMT5 substrates associated with AML proliferation outlined by Radzisheuskaya et al., 2019. (A) The eleven PRMT5 substrate genes identified as responsible for proliferation in AML and their functions. The genes in bold represent the nine genes that are involved in RNA metabolism and splicing. (B) The nine RNA metabolism and splicing proteins that are methylated by PRMT5 and whereabouts they act in the process of RNA metabolism and splicing.