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The inhibition of MAT2A exacerbates the reduction in PRMT5 activity present in a MTAP-negative background. Here, we show the changes in PRMT5 activity over different genetic backgrounds [MTAP-positive (A) and MTAP-negative (B)] and in an MATZA inhibited state within an MTAP-negative background (C). The outcome of these differences is a change in levels of methylation of PRMT5 targets.
