Table 1.
PRMT5 targets.
| PRMT5 target | Function | PRMT5 action on target | Cell line/cancer type | Citation |
|---|---|---|---|---|
| ALYREF | Pre-mRNA transport and splicing | Methylation of protein | THP-1 (AML) | (37) |
| AR | Tumour promoting gene | Increased expression via epigenetic regulation | LNCaP, C4-2 (Prostate cancer) | (42) |
| C-Myc | Regulate NF-κB pathway | Increased expression and stabilise protein | T24, 5637 (Bladder cancer), MUA PaCa-2, SW1990 (Pancreatic cancer) | (41, 43) |
| CANNTG | C-Myc-binding E-box element | Reduced expression of downstream genes via epigenetic regulation | BGC823 and SGC7901 (Gastric cancer) | (35) |
| CCNE1 | G1/S transition via CDK2 regulation | Reduced expression via epigenetic regulation | U2OS | (44) |
| CCT4 | Component of TRiC complex | Methylation of protein | THP-1 (AML) | (37) |
| CCT7 | Component of TRiC complex | Methylation of protein | THP-1 (AML) | (37) |
| CD74 | Component of MHC II molecule | Reduced expression via epigenetic regulation | Liver cancer | (45) |
| CDH1 | Tumour suppressor gene | Reduced expression via epigenetic regulation | A549 (Lung cancer) | (46) |
| CIITA | Component of MHC II molecule | Reduced expression via epigenetic regulation | Liver cancer | (45) |
| CPSF6 | 3’ RNA cleavage and polyadenylation | Methylation of protein | THP-1 (AML) | (37) |
| E2F1 | Transcription factor that can regulate apoptosis | Methylation and destabilisation of protein | U2OS | (47) |
| FA genes | Inter-strand crosslink (CIL)-induced DNA damage repair | Increased expression via epigenetic regulation | U251MG, T98G, U118MG (Glioblastoma) | (48) |
| FBW7 | C-Myc regulator gene | Reduced expression via epigenetic regulation | PaCa-2, SW1990 (Pancreatic cancer) | (41) |
| FOXP1 | Activates oestrogen receptor (ER) | Increased expression via epigenetic regulation | MCF7 (Breast cancer) | (34) |
| IFI16 (IFI204) | Regulator of STING/cGAS signalling pathway | Methylation of protein to control function | A375, WM115, B16 (Melanoma) | (49) |
| Mxi1 | C-Myc agonist | Methylation of protein leading to degradation | H1299, A549, H460, H522, H358 (NSCLC) | (50) |
| NLRC5 | Regulator of MHC I gene expression | Decreased expression of gene | B16, CCLE melanoma cell lines (Melanoma) | (49) |
| NM23 | Tumour suppressor gene | Reduced expression via epigenetic regulation | NIH/3T3 | (51) |
| p53 | Promotes cell cycle arrest to allow DNA repair, regulates apoptosis | Methylation of protein to inactivate pro-apoptotic function | U2OS, HSPCs | (52, 53) |
| PNN | Part of exon junction complex (EJC) | Methylation of protein | THP-1 (AML) | (37) |
| RPS10 | Component of the 40S ribosomal subunit | Methylation of protein | THP-1 (AML) | (37) |
| RUVBL1 | Component of TIP60 complex for directing DNA damage repair towards the HR pathway | Methylation of protein to allow complex formation | HeLa (Cervical cancer) | (54) |
| SFPQ | Early splicing factor | Methylation of protein | THP-1 (AML) | (37) |
| Sm proteins | Formation of the spliceosome | Methylation required for smRNP biogenesis | HeLa (Cervical cancer) | (55) |
| SNAIL1 | Epithelial-mesenchymal transition (EMT) and metastatic activator factor | Increased expression via epigenetic regulation | A549 (Lung cancer) | (46) |
| SNRPB | Component of SMN-Sm complex | Methylation of protein | THP-1 (AML) | (37) |
| SPDEF | Tumour suppressor gene | Reduced expression via epigenetic regulation | A549 (Lung cancer) | (46) |
| SRSF1 | Prevents exon skipping | Methylation of protein | THP-1 (AML) | (37) |
| ST7 | Tumour suppressor gene | Reduced expression via epigenetic regulation | NIH/3T3 | (51) |
| SUPT5H | mRNA processing, transcription and elongation of RNAP II | Methylation of protein | THP-1 (AML) | (37) |
| VIM | Epithelial-mesenchymal transition (EMT) and metastatic activator factor | Increased expression via epigenetic regulation | A549 (Lung cancer) | (46) |
| WDR33 | mRNA polyadenylation | Methylation of protein | THP-1 (AML) | (37) |
| ZNF326 | Subunit of DBIRD complex that regulates alternative splicing | Methylation requires for accurate splicing | MDA-MB-231 (Breast cancer) | (56) |