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. 2023 Sep 19;13:1264785. doi: 10.3389/fonc.2023.1264785

Table 2.

Protein arginine methyltransferase 5 inhibitors.

Drug Name Structure Clinical trial
identifier (if
applicable)		 Clinical trial stage (if
applicable)		 Cancer type in trial
(if applicable)		 Citation
EPZ015666/
GSK3326595		 graphic file with name fonc-13-1264785-i001.jpg NCT04676516 Phase 2 Early-stage breast cancer (83)
LLY-283 graphic file with name fonc-13-1264785-i002.jpg (85)
JNJ-64619178 graphic file with name fonc-13-1264785-i003.jpg NCT03573310 Phase 1 Neoplasms, Solid tumour (adult), Non-Hodgkin Lymphoma, Myelodysplastic Syndromes (86, 87)
BRD0639 graphic file with name fonc-13-1264785-i004.jpg (90)
AMG193 Not published NCT05094336 Phase 1/2 MTAP-null solid tumours No publications
TNG908 Not published NCT05275478 Phase 1/2 MTAP-null solid tumours No publications
SCR-6920 Not published NCT05528055 Phase 1 Solid tumour, Non-Hodgkin Lymphoma No publications
PRT543 Not published NCT03886831 Phase 1 Solid tumours/
lymphomas, Haematological malignancies		 No publications
PRT811 Not published NCT04089449 Phase 1 Advanced solid tumour, Recurrent Glioma No publications
MRTX1719 graphic file with name fonc-13-1264785-i005.jpg NCT05245500 Phase 1/2 Mesothelioma, Non-small cell lung cancer, Malignant peripheral nerve sheath tumour, Solid tumours, Pancreatic adenocarcinoma (89)