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. 2023 Sep 19;13:1264785. doi: 10.3389/fonc.2023.1264785

Table 3.

Methionine adenosyltransferase II alpha inhibitors.

Drug Name Structure Clinical trial identifier (if applicable) Clinical trial stage (if applicable) Cancer type in trial
(if applicable)		 Citation
Cycloleucine graphic file with name fonc-13-1264785-i006.jpg (91)
Aminobicyclo-hexane-carboxylic acid graphic file with name fonc-13-1264785-i007.jpg (92)
FIDAS agents (generic structure) - X, Y and Z are variable groups graphic file with name fonc-13-1264785-i008.jpg (93, 94)
PF-9366 graphic file with name fonc-13-1264785-i009.jpg (95)
AGI-25696 graphic file with name fonc-13-1264785-i010.jpg (96)
AG-270 (S095033) graphic file with name fonc-13-1264785-i011.jpg NCT03435250, NCT05312372 Phase 1,
Phase 1/2		 Advanced solid tumours, Lymphoma, Oesophageal squamous cell carcinoma (74)
Compound 28 graphic file with name fonc-13-1264785-i012.jpg (97)
IDE397 Not published NCT04794699 Phase 1 Solid tumour No publications