Figure 1:

(A) Diagram shows the inclusion of patients into the study. (B) Diagram shows the iterative annotation workflow of the training dataset. Steps involving manual annotation are shown in green. In step 9, a completely new model was trained independently of the intermediate models (steps 2, 4, and 6). This avoids leakage of information from the test set into the training set. PACS = picture archiving and communication system.