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. 2023 Sep 18;14:1243946. doi: 10.3389/fimmu.2023.1243946

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Copyright © 2023 Rezk, Pittock, Kapadia, Knight, Guo, Gupta, LaFrance-Corey, Zekeridou, McKeon, Dasari, Mills and Dubey

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Disease course and clinical studies in SKOR2 IgG-positive patients. (A) Graphic time course of events for Case 1. Major events are indicated in black. (B) FLAIR sequence of the MRI shows hyperintensities in the left external capsule, insula, and thalamus ((B1), arrowhead). The hypermetabolic lesion in the left upper lobe (arrow) was confirmed by biopsy to be lung adenocarcinoma (B2). Post-immunotherapy MRI shows the resolution of findings observed on the first MRI ((B3), arrowhead). A recurrence of the left insular hyperintensity can be seen (B4). The last follow-up MRI demonstrated global volume loss (B5). (C) Graphic time course of events for Case 2. Major events are indicated in black.